Distinct molecular features of colorectal carcinoma with signet ring cell component and colorectal carcinoma with mucinous component

Clinicopathologic and Molecular Features of Colorectal Adenocarcinoma with Signet-Ring Cell Component

BACKGROUND We performed a retrospective study to assess the clinicopathological characters, molecular alterations and multigene mutation profiles in colorectal cancer patients with signet-ring cell component. METHODS Between November 2008 and January 2015, 61 consecutive primary colorectal carcinomas with signet-ring cell component were available for pathological confirmation. RAS/BRAF status...

BRAF mutation in colorectal carcinomas with signet ring cell component

OBJECTIVE : Signet ring cell carcinoma is a rare subtype of colorectal carcinoma (CRC) with an associated BRAFV600E mutation. We investigated frequencies of BRAF mutation in 28 CRCs containing variable signet ring cell component and their relation with clinicopathologic parameters. METHODS : According to the presence of signet ring cell component, tumors were categorized into groups as follow...

Impact of Microsatellite Instability in Signet-Ring Cell and Mucinous Components in Patients With Colorectal Carcinoma

The disease pathogenesis of colorectal cancer (CRC) is influenced by genetic and epigenetic events that occur with tumor initiation and progression [1]. Diagnostic approaches have evolved from relying exclusively on clinical criteria to incorporating pathologic features such as mucinous and signet-ring cell (SRC) carcinomas, PCR-based microsatellite instability (MSI) testing, and immunohistoche...

Signet-ring cell carcinoma of colorectum – current perspectives and molecular biology REVIEW: Running title: Colorectal signet-ring carcinoma

Sarcomatoid Chromophobe Renal Cell Carcinoma with Heterologous Component

Clear cellrenal cell carcinoma (RCC) is the most common malignant renal tumor in adults, while chromophobe RCC (CRCC) is the third most common. Any subtypes of RCC can undergo sarcomatoid differentiation, but heterologous differentiation in sarcomatoid area is very rare in RCC. Here a61-year male is presented with hematuria and palpable mass. Clinicoradiologically, RCC was considered and left r...